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Researcher profile

T Utsugi

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Publications

1 research record shown

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 · PubMed · DOI 10.1038/36285

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

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Co-authors

M Kuro-o

National Center of Neurology and Psychiatry

1 shared publication
Y Matsumura

The University of Texas Medical Branch at Galveston

1 shared publication
H Aizawa

1 shared publication
H Kawaguchi

The University of Texas Health Science Center at Houston

1 shared publication
T Suga

1 shared publication
Y Ohyama

1 shared publication
M Kurabayashi

1 shared publication
T Kaname

1 shared publication
E Kume

1 shared publication
H Iwasaki

1 shared publication
A Iida

1 shared publication
T Shiraki-Iida

1 shared publication