TY  - JOUR
TI  - Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology
AU  - Mamona Nazir
AU  - Muhammad Saleem
AU  - Muhammad Imran Tousif
AU  - Muhammad Aijaz Anwar
AU  - Frank Surup
AU  - Iftikhar Ali
AU  - Daijie Wang
AU  - Nilufar Z. Mamadalieva
AU  - Elham Alshammari
AU  - Mohamed L. Ashour
AU  - Ahmed M. Ashour
AU  - Ishtiaq Ahmed
AU  - Elizbit
AU  - Ivan R. Green
AU  - Hidayat Hussain
PY  - 2021
JO  - Biomolecules
DO  - 10.3390/biom11070957
UR  - https://doi.org/10.3390/biom11070957
AB  - Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.
ER  -