TY  - JOUR
TI  - Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019
AU  - Jonathan Kocarnik
AU  - Kelly Compton
AU  - Frances Dean
AU  - Weijia Fu
AU  - Brian Gaw
AU  - James Harvey
AU  - Hannah Henrikson
AU  - Dan Lu
AU  - Alyssa Pennini
AU  - Rixing Xu
AU  - Emad Ababneh
AU  - Mohsen Abbasi‐Kangevari
AU  - Hedayat Abbastabar
AU  - Sherief Abd‐Elsalam
AU  - Amir Abdoli
AU  - Aidin Abedi
AU  - Hassan Abidi
AU  - Hassan Abolhassani
AU  - Isaac Akinkunmi Adedeji
AU  - Qorinah Estiningtyas Sakilah Adnani
AU  - Shailesh M Advani
AU  - Muhammad U. Afzal
AU  - Mohammad Aghaali
AU  - Bright Opoku Ahinkorah
AU  - Sajjad Ahmad
AU  - Tauseef Ahmad
AU  - Ali Ahmadi
AU  - Sepideh Ahmadi
AU  - Tarik A. Rashid
AU  - Yusra Ahmed Salih
AU  - Gizachew Taddesse Akalu
AU  - Addis Aklilu
AU  - Tayyaba Akram
AU  - Chisom Joyqueenet Akunna
AU  - Hanadi Al Hamad
AU  - Fares Alahdab
AU  - Ziyad Al‐Aly
AU  - Saqib Ali
AU  - Yousef Alimohamadi
AU  - Vahid Alipour
AU  - Syed Mohamed Aljunid
AU  - Motasem Alkhayyat
AU  - Amir Almasi‐Hashiani
AU  - Nihad A. Almasri
AU  - Sadeq Ali Al‐Maweri
AU  - Sami Almustanyir
AU  - Nivaldo Alonso
AU  - Nelson Alvis‐Guzmán
AU  - Hubert Amu
AU  - Etsay Woldu Anbesu
AU  - Robert Ancuceanu
AU  - Fereshteh Ansari
AU  - Alireza Ansari‐Moghaddam
AU  - Maxwell Hubert Antwi
AU  - Davood Anvari
AU  - Anayochukwu Edward Anyasodor
AU  - Muhammad Aqeel
AU  - Jalal Arabloo
AU  - Morteza Arab‐Zozani
AU  - Olatunde Aremu
AU  - Hany Ariffin
AU  - Timur Aripov
AU  - Muhammad Arshad
AU  - Al Artaman
AU  - Judie Arulappan
AU  - Zatollah Asemi
AU  - Mohammad Asghari Jafarabadi
AU  - Tahira Ashraf
AU  - Prince Atorkey
AU  - Avinash Aujayeb
AU  - Marcel Ausloos
AU  - Atalel Fentahun Awedew
AU  - Beatriz Paulina Ayala Quintanilla
AU  - Temesgen Ayenew
AU  - Mohammed A. Azab
AU  - Sina Azadnajafabad
AU  - Amirhossein Azari Jafari
AU  - Ghasem Azarian
AU  - Ahmed Y. Azzam
AU  - Ashish Badiye
AU  - Saeed Bahadory
AU  - Atif Amin Baig
AU  - Jennifer L. Baker
AU  - Senthilkumar Balakrishnan
AU  - Maciej Banach
AU  - Till Bärnighausen
AU  - Francesco Barone‐Adesi
AU  - Fabio Barra
AU  - Amadou Barrow
AU  - Masoud Behzadifar
AU  - Uzma Belgaumi
AU  - Woldesellassie Bezabhe
AU  - Yihienew Mequanint Bezabih
AU  - Devidas S. Bhagat
AU  - Akshaya Srikanth Bhagavathula
AU  - Nikha Bhardwaj
AU  - Pankaj Bhardwaj
AU  - Sonu Bhaskar
AU  - Krittika Bhattacharyya
AU  - Vijayalakshmi S Bhojaraja
PY  - 2021
JO  - JAMA Oncology
DO  - 10.1001/jamaoncol.2021.6987
UR  - https://doi.org/10.1001/jamaoncol.2021.6987
AB  - IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.
ER  -