University of KwaZulu-Natal

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015

IMPORTANCE: Cancer is the second leading cause of death worldwide. Current estimates on the burden of cancer are needed for cancer control planning. OBJECTIVE: To estimate mortality, incidence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 32 cancers in 195 countries and territories from 1990 to 2015. EVIDENCE REVIEW: Cancer mortality was estimated using vital registration system data, cancer registry incidence data (transformed to mortality estimates using separately estimated mortality to incidence [MI] ratios), and verbal autopsy data. Cancer incidence was calculated by dividing mortality estimates through the modeled MI ratios. To calculate cancer prevalence, MI ratios were used to model survival. To calculate YLDs, prevalence estimates were multiplied by disability weights. The YLLs were estimated by multiplying age-specific cancer deaths by the reference life expectancy. DALYs were estimated as the sum of YLDs and YLLs. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. Countries were categorized by SDI quintiles to summarize results. FINDINGS: In 2015, there were 17.5 million cancer cases worldwide and 8.7 million deaths. Between 2005 and 2015, cancer cases increased by 33%, with population aging contributing 16%, population growth 13%, and changes in age-specific rates contributing 4%. For men, the most common cancer globally was prostate cancer (1.6 million cases). Tracheal, bronchus, and lung cancer was the leading cause of cancer deaths and DALYs in men (1.2 million deaths and 25.9 million DALYs). For women, the most common cancer was breast cancer (2.4 million cases). Breast cancer was also the leading cause of cancer deaths and DALYs for women (523 000 deaths and 15.1 million DALYs). Overall, cancer caused 208.3 million DALYs worldwide in 2015 for both sexes combined. Between 2005 and 2015, age-standardized incidence rates for all cancers combined increased in 174 of 195 countries or territories. Age-standardized death rates (ASDRs) for all cancers combined decreased within that timeframe in 140 of 195 countries or territories. Countries with an increase in the ASDR due to all cancers were largely located on the African continent. Of all cancers, deaths between 2005 and 2015 decreased significantly for Hodgkin lymphoma (-6.1% [95% uncertainty interval (UI), -10.6% to -1.3%]). The number of deaths also decreased for esophageal cancer, stomach cancer, and chronic myeloid leukemia, although these results were not statistically significant. CONCLUSION AND RELEVANCE: As part of the epidemiological transition, cancer incidence is expected to increase in the future, further straining limited health care resources. Appropriate allocation of resources for cancer prevention, early diagnosis, and curative and palliative care requires detailed knowledge of the local burden of cancer. The GBD 2015 study results demonstrate that progress is possible in the war against cancer. However, the major findings also highlight an unmet need for cancer prevention efforts, including tobacco control, vaccination, and the promotion of physical activity and a healthy diet.

The future of quantum biology

Biological systems are dynamical, constantly exchanging energy and matter with the environment in order to maintain the non-equilibrium state synonymous with living. Developments in observational techniques have allowed us to study biological dynamics on increasingly small scales. Such studies have revealed evidence of quantum mechanical effects, which cannot be accounted for by classical physics, in a range of biological processes. Quantum biology is the study of such processes, and here we provide an outline of the current state of the field, as well as insights into future directions.

Reproductive biology of Australian acacias: important mediator of invasiveness?

Abstract Aim Reproductive traits are important mediators of establishment and spread of introduced species, both directly and through interactions with other life‐history traits and extrinsic factors. We identify features of the reproductive biology of Australian acacias associated with invasiveness. Location Global. Methods We reviewed the pollination biology, seed biology and alternative modes of reproduction of Australian acacias using primary literature, online searches and unpublished data. We used comparative analyses incorporating an Acacia phylogeny to test for associations between invasiveness and eight reproductive traits in a group of introduced and invasive (23) and non‐invasive (129) species. We also explore the distribution of groups of trait ‘syndromes’ between invasive and non‐invasive species. Results Reproductive trait data were only available for 126 of 152 introduced species in our data set, representing 23/23 invasive and 103/129 non‐invasive species. These data suggest that invasives reach reproductive maturity earlier (10/13 within 2 years vs. 7/26 for non‐invasives) and are more commonly able to resprout (11/21 vs. 13/54), although only time to reproductive maturity was significant when phylogenetic relationships were controlled for. Our qualitative survey of the literature suggests that invasive species in general tend to have generalist pollination systems, prolific seed production, efficient seed dispersal and the accumulation of large and persistent seed banks that often have fire‐, heat‐ or disturbance‐triggered germination cues. Conclusions Invasive species respond quicker to disturbance than non‐invasive taxa. Traits found to be significant in our study require more in‐depth analysis involving data for a broader array of species given how little is known of the reproductive biology of so many taxa in this species‐rich genus. Sets of reproductive traits characteristic of invasive species and a general ability to reproduce effectively in new locations are widespread in Australian acacias. Unless there is substantial evidence to the contrary, care should be taken with all introductions.

The biology of filter feeding teleosts in Lake St Lucia, Zululand

The biology of filter feeding teleosts in St Lucia, was studied for two years from 1976 to 1978. The three common species, Gilchristella aestuarius, Hilsa kelee and Thryssa vitrirostris were studied with the composition and cyclical nature of the zooplankton which formed their food. Stolephorus commersonii and Hepsetia breviceps which were rare were only briefly examined. The zooplankton was dominated by the calanoid Pseudodiaptomus stuhlmanni which formed > 70 % of the calorific value of the zooplankton for 70 % of the study period. The mysid Mesopodopsis africana was second in importance in terms of calorific contribution while the amphipod Grandidierella lignorum was relatively abundant. Larval forms, particularly post‐veligers of Assiminea bifasciata were also important. There was a close correlation between the zooplankton cycles, both diel and annual, and the feeding, reproduction and recruitment of the three common filter feeding teleosts. G. aestuarius spent its whole life‐cycle in the system and spawned in early summer when the resulting juveniles could feed on the summer zooplankton peaks. They grew at 0.5 cm month −1 and attained maximum size in one year. They were non‐selective taking mainly P. stuhlmanni and post‐veligers. H. kelee spawned in the sea and juveniles were common in St Lucia during 1978 when they fed non‐selectively, chiefly on P. stuhlmanning the summer before disappearing over the winter. The resulting offspring went through a sequence of dietary changes which were closely related to zooplankton cycles. The importance of P. stuhlmanni in the pelagic food web of St Lucia is illustrated. The species supports not only the filter feeding teleosts but indirectly the predatory fish Argyrosomus hololepidotus and Elops machnata which feed on G. aestuarius and T. vitrirostris .

The biology and potential biotechnological applications of Bacillus safensis

The biology of Carangidae (Teleostei) in Natal estuaries

The occurrence and abundance of 17 species of Carangidae in Natal estuaries are described. The following six species are of significance in the estuarine community: Caranx ignobilis, C. melampygus, C. papuensis, C. sexfasciatus, Lichia amia and Scomberoides lysan . Only juveniles and subadults utilize estuaries. The time of recruitment, growth rates and feeding biology of the six species were investigated. Among the juveniles, C. ignobilis and C. sexfasciatus are mainly piscivorous on a variety of small estuarine fishes and estuarine dependent juveniles of marine species, while C. melampygus, C. papuensis and S. lysan filter feed on mysids and juvenile penaeids. Subadults of all species are piscivorous, although C. papuensis and S. lysan retain a suitable gill raker structure for filter feeding and a proportion of their diet consists of mysids and penaeids. The salinity and turbidity preferences of each species were investigated. All are euryhaline but C. melampygus, C. papuensis and 5. lysan are only found in clear water. It is suggested that the more widespread estuarine distribution of juvenile C. sexfasciatus and C. ignobilis may be related to their turbidity tolerances. The role of carangids in Natal estuaries is discussed in relation to their ecological significance in estuaries as predators and their degree of estuarine dependence.